This preprint provides insights into the functional dynamics of mitochondria-lipid droplet interactions and highlights potential therapeutic targets for lipid metabolic disorders and non-alcoholic fatty liver disease.
The first paper that introduces Microscoop microscopy, photo-biotinylation and mass spectrometry for unprecedented protein localization and identification.
Cell surface proteins are key biomarkers and therapeutic targets, but profiling the surfaceome is challenging. Using Syncell Microscoop® with Synlight-Rich (~350 nm) or Synlight-Pure (~25–50 nm), proteins in microscopy-defined regions are selectively tagged for LC-MS/MS analysis. This enables deep, unbiased mapping of plasma membrane and subcellular proteomes, with Synlight-Pure boosting specificity to ~90%, supporting biomarker discovery and therapeutic target identification in oncology, neurodegeneration, and immunology.
