High-Precision Spatial Proteomics Platform | Syncell

PROTEIN PURIFICATION
BY MICROSCOPIC SELECTION

IMAGE-DIRECTED PHOTOPROXIMITY LABELING FOR
NOVEL SUBCELLULAR PROTEOMES

NOW IT’S POSSIBLE TO

Reveal protein constituents at any specific subcellular regions of interest under a microscope

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Discover novel protein contents at disease-associated features/locations

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Achieve unbiased high-precision proteomic discovery of FFPE/fresh frozen tissue samples or fixed cell culture samples

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Resolve limitations of proximity labeling, laser capture microdissection, or mass spectrometry imaging methods

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Uncover the players of the tissue microenvironment in cancer and/or the immune systems

Define new cell types and states by identifying unique protein markers

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PIONEERING Products

Microscoop® Mint

Microscoop® is the only spatial proteomics platform designed to enable high-precision, unbiased discovery of the entire proteome at the cellular and subcellular level.

Reagents and Consumables  

Reagent kits are specifically designed and optimized to integrate flawlessly with the Microscoop system for spatial protein purification and proteomic discovery.

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This technology allows us to identify potential biomarkers for future diagnostics or therapeutic targets in an unbiased manner—achievements not possible with other spatial biology methods.

Wilfried Rossoll, Ph.D., Mayo Clinic

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This Microscoop system can help us to capture the proteomes in or adjacent to the interested subcellular regions in situ, and we haven’t found any other instruments can do this at present.

Dr. Wang, Hangzhou Institute of Medicine CAS

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Its flexibility will enable us to detect new protein expression patterns, reveal hidden cellular interactions, and link spatial protein signatures to key phenotypes. Used with high-sensitivity mass spectrometry, Syncell’s Microscoop Mint could help predict or improve clinical outcomes for complex diseases and answer fundamental biological questions studied at VIB.

Bram Van den Bergh, Ph.D., VIB

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Chuan-Wei (David) Jang ’s training was fantastic and truly inspired our team! We’re excited to dive into LC-MS–backed spatial proteomics to uncover subcellular secrets. We look forward to delivering data to our clinical and pharma partners that is not only visually stunning but also rich in molecular precision.

Dr. Saewhan Park, Senior Manager of Proteomic Analysis., ONCOCROSS Co., Ltd

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Thanks for the amazing training. We are excited to explore the possibility of subcellular spatial proteomics.

Dr. Mann’s team, Max Planck Institute of Biochemistry in Matthias Mann’s lab

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We are excited to utilize the Microscoop technology to characterize mitochondria on the subcellular level.

Dr. Hendrik Nolte, Max Planck Institute for Biology of Ageing in Cologne

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The Ciliarium had an exceptionally exciting week… We can’t wait to begin our pilot experiment!

Roepman Lab

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Spotlight

Introducing Synlight-Pure: Enabling Nanoscopic Proteomics

Learn how nanoscopic photolabeling transforms proteome discovery, revealing biology at the precision of the molecular interaction level.

Where Discovery Proteomics Meets Spatial Precision: How FMP Is Accelerating Biological Insights with Microscoop®

Microscoop® Enables Subcellular Proteomic Discovery of Stress Granules

Pushing the Limits Unveiling Proteome of Primary Cilia at Unprecedented Resolution Using Microscoop®

Integrating Spatial Discovery with Spatial Profiling to reveal the Depths of Cellular Architecture