Syncell Discovery Services

Discovery-grade insights for target and biomarker discovery, and more

Reveal the biology other methods miss.

From organelle contact-site proteomics and signaling dynamics to astrocyte profiling and target discovery, Syncell delivers unmatched, end-to-end nanoscopic proteomics with spatial precision.

We use our state-of-the-art Microscoop Platform and Synlight reagents to achieve the highest resolution spatial proteomics purification and analysis method with extremely high sensitivity. Our team will work with you to understand your specific project needs and provide end-to-end services, from sample to protein discovery, delivering true biological insights. Powered by the same team that invented the technology, our offering is designed for researchers who demand unbiased proteomic insights.

What We Do

Syncell is a specialized discovery partner focused on providing scientists with nanoscopic proteomics insights to enable more confident and actionable research. Our services go beyond data generation—we deliver decision-ready biological insight that informs prioritization, reduces risk, and accelerates programs.

Key Capabilities

Microscopy-targeted ROI selection

Automated nanoscopic photo-biotinylation

Mass spectrometry analysis

Robust statistical interpretation

Scientific report with prioritized hypotheses

Why Syncell Discovery Services Matter

Modern drug discovery is driven by context-aware biology. Standard proteomics often averages signals across whole cells or tissues, missing the localized protein interactions that define mechanisms of action, target relevance, and biomarker potential. Syncell’s approach gives you spatially precise proteomes tied to your biology of interest.

Pharma Discoveries We Support

Target nomination & prioritization
Mechanism of action elucidation
Biomarker hypothesis generation
Comparative profiling across conditions

Beyond drug discovery, Syncell Discovery Services are equally powerful for fundamental and translational biology questions where spatial context defines function. Our platform enables researchers to move beyond bulk proteomics and uncover protein networks within precisely defined subcellular regions, cell types, and microenvironments.

Academic & Translational Discoveries We Support

Neuroscience & Neurodegeneration: Synaptic subtype proteomics, Stress granules and TDP-43 aggregates, region-specific protein signatures
Oncology & Immunology: Tumor microenvironment interactions, Oncogenic condensates and nuclear bodies, Treatment response profiling at subcellular resolution
Cell Biology & Organelle Function: Organelle contact sites (ER–mitochondria, mitochondria-lipid droplet), Phase-separated condensates, Membrane damage responses, Subcellular signaling hubs
Comparative & Condition-Dependent Biology: Mutant vs. wild-type comparisons, Disease vs. healthy tissue, Time-course or perturbation studies

Service Packages

Signature Discovery Project

Baseline proteomic signature for one region/condition. Ideal for: early target or pathway exploration.

Comparative Profiling Project

Contrast proteomes across conditions (e.g., treated vs control). Ideal for: hypothesis testing & mechanistic understanding.

Program Partnership

Multi-study engagements with strategic design and ongoing scientific collaboration.

Each project includes biological replicates, QC, MS analysis, and expert interpretation.

How We Work

Syncell operates like a niche discovery CRO—with deep domain expertise and a streamlined workflow designed for clarity and action:

✔ Collaborative study design

✔ In-process quality checks

✔ High-precision data generation

✔ Statistical rigor for confident decisions

This is not a self-service platform—it’s a partnership with experts who understand how proteomics drives discovery.

Engagement Criteria

To focus on studies with true discovery impact, Syncell engages on projects that meet the following minimums:

Project budget ≥ $50,000
≥ 3 biological samples (biological replicates)

These criteria ensure statistically informative data and meaningful insight for your program.

You’re in Good Company

Syncell Discovery Services help research teams uncover biology not accessible with conventional proteomics—revealing novel protein patterns, mechanistic detail, and biomarker candidates that guide better decisions without building internal infrastructure.