A Microscoop® stress granule study identified 1,754 consistently enriched proteins with 96% specificity among the top 50 ranked, including novel SG-associated proteins, uncovering potential therapeutic targets for stress-related diseases.
Syncell Microscoop® integrates cutting-edge microscopy, photo-biotinylation, and mass spectrometry to enable high-resolution, hypothesis-free protein discovery. The platform identifies and isolates proteins from specific cellular structures, such as nuclei, stress granules, and primary cilia, paving the way for advancements in diagnostics, therapeutic development, and disease research.
High-sensitivity, hypothesis-free spatial proteomics by integrating microscopy-guided photo-biotinylation with LC-MS/MS analysis identifies and maps proteins within compartments such as nuclei, nucleoli, stress granules, and primary cilia.
Integrating real-time image segmentation, two-photon photolabeling, and mass spectrometry-based proteomics, Microscoop reveals key regulators of mitochondrial-LD interactions, providing new insights into lipid metabolism and inter-organelle communication.
Microscoop® selectively labels and analyzes primary cilia proteins within subcellular regions of interest, uncovering new ciliary proteins and their interactions.
A new study shows how Microscoop® maps the poorly understood immune synapse-localized proteome more with nanoscale precision, discovering previously uncharacterized proteins and protein-protein interactions, offering new insights into immune synapse biology and potential therapeutic targets in immune-oncology.
