High-sensitivity, hypothesis-free spatial proteomics by integrating microscopy-guided photo-biotinylation with LC-MS/MS analysis identifies and maps proteins within compartments such as nuclei, nucleoli, stress granules, and primary cilia.
Integrating real-time image segmentation, two-photon photolabeling, and mass spectrometry-based proteomics, Microscoop reveals key regulators of mitochondrial-LD interactions, providing new insights into lipid metabolism and inter-organelle communication.
Microscoop® selectively labels and analyzes primary cilia proteins within subcellular regions of interest, uncovering new ciliary proteins and their interactions.
A new study shows how Microscoop® maps the poorly understood immune synapse-localized proteome more with nanoscale precision, discovering previously uncharacterized proteins and protein-protein interactions, offering new insights into immune synapse biology and potential therapeutic targets in immune-oncology.
Microscoop® enables microscopy-guided automated photo-biotinylation to identify proteins associated with amyloid-β (Aβ) aggregates, a hallmark of Alzheimer’s disease, including Lon protease and DDX3X helicase using AI-driven segmentation and high-precision mass spectrometry.
