Drug Discovery & Development

Unlock Spatial Proteomics for Drug Discovery

Reveal unseen biology. De-risk your pipeline.

Modern pharmaceutical research demands a deeper understanding of biology in context. Syncell’s Microscoop Mint delivers unbiased, label-free spatial proteomics that reveals protein function where it matters most: in the spatial architecture of tissue.

Microscoop Mint helps drug developers

Identify novel, spatially relevant targets

Elucidate mechanisms of action (MOA)

Accelerate biomarker discovery

De-risk assets through early safety and efficacy insights

On-demand Webinar

Unveiling Novel Proteins at the Mitochondria-Lipid Droplet Interface

In this webinar, you will discover how the Microscoop Mint platform combines advanced two-photon excitation microscopy with cutting-edge spatial proteomics to target and enrich proteins at mitochondria-LD contact sites with unparalleled nanoscale precision.

Pharmaceutical Applications

Target Discovery & Validation

Go beyond genomics. Microscoop Mint enables detection of spatially and functionally relevant protein targets that transcriptomics or bulk proteomics miss.

Discover novel targets in subcellular compartments
Avoid limitations of pre-selected antibody panels
Detect proteins in situ, including those not captured in transcriptomic data

Mechanism of Action (MOA) Elucidation

Understand exactly where and how a drug is working—or failing. Spatial proteomics uncovers compartment-specific effects, enabling early differentiation of responders and non-responders.

Map functional changes within tissue microenvironments
Track off-target activity at the protein level
Localize drug-protein interactions in their native context

Biomarker Discovery & Translation

Microscoop Mint bridges transcriptomics and proteomics by validating RNA hits directly in tissue, without the need for antibodies.

Works on FFPE and fresh-frozen tissue
Provides proteomic context that complements scRNA-seq and targeted methods
Enables spatial validation of transcriptomic leads

Safety Pharmacology & Spatial TOX Profiling

Mitigate late-stage failure by detecting early protein-level markers of toxicity and off-target effects.

Profile healthy vs. diseased tissue spatially
Identify unanticipated protein expression patterns
Guide repurposing by detecting off-target biology in relevant compartments

WHY MICROSCOOP MINT?

FEATURE

VALUE TO PHARMA

Subcellular resolution (~350nm)

Detect effects invisible to traditional proteomics

Label-free, antibody-free

Avoid the biases and limits of antibody panels

Compatible with FFPE & fresh-frozen

Leverage archival and prospective tissue samples

Streamlined workflows

Scale across patient cohorts or tissue types

A Tool for
Translational
Precision

From oncology to CNS disorders, Microscoop Mint helps drug developers uncover actionable insights at every stage of discovery and development. Its unique capabilities position spatial proteomics as a cornerstone of precision pharmacology.

Ready to see what your targets are doing—and where?

Explore how Syncell’s Microscoop Mint can transform your translational research.