Microscoop^® Enables Subcellular Proteomic Discovery of Stress Granules

Microscoop^® is a cutting-edge platform enabling precise subcellular spatial proteomics through image-guided photo-biotinylation and LC-MS/MS analysis. In a study of stress granules (SGs), Microscoop identified 1,754 consistently enriched proteins with 96% specificity among the top 50 ranked, including novel SG-associated proteins. This innovative system advances our understanding of SG biology, uncovering potential therapeutic targets and paving the way for new treatments in stress-related diseases.