In this study, the amyloid-β (Aβ) peptide Aβ1-42 was overexpressed in a neuronal cell line to induce aggregate formation—pathological hallmarks of Alzheimer’s disease. Using image-based recognition and photolabeling, Microscoop precisely biotinylated Aβ aggregates, enabling targeted proteomic analysis of these disease-relevant structures.
Colocalization of Aβ1-42 (red) with biotin tags (green) highlights Microscoop’s ability to precisely label Aβ-localized proteins and subsequently map the proteomic landscape of pathological aggregates directly within complex neural environments.
